Progress in Src protein
- VernacularTitle:Src蛋白研究进展
- Author:
Jie XIE
;
Xingguo GONG
;
Dongyun ZENG
- Publication Type:Journal Article
- Keywords:
Oncogene protein c-src;
Focal adhesion kinase;
Cell movement;
Cell survival;
Signal transduction;
Neoplasms
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Src is a non-receptor protein tyrosine kinase activated by a number of extracellular signal moleculars. It is recruited to peripheral sites through myristoylation and the SH3 domain. Src initiates intracellular signal trandsduction pathways that influence cell adhesion, migration, growth, differentiation and survival though catalytic domain. Src is normally maintained in an inactive conformation because of carboxy terminal Src kinase, but can be activated transiently during cellular events such as mitosis or constitutively by abnormal events such as mutation and some cancers. In additions, c-Src protein is found to be highly activated and the Src gene is frequently over-expressed in many cancers. These findings suggest that the relationship between c-Src activation/over-expression and cancer progression appears to be significant.
