Molecular mechanism of immune cells activated by bacterial DNA
- VernacularTitle:细菌DNA激活免疫细胞的分子机制
- Author:
Liangxi WANG
;
Hong ZHOU
- Publication Type:Journal Article
- Keywords:
DNA, bacterial;
Immunity, cellular;
Endosomes;
Signal transduction;
Inflammation
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Bacterial DNA taken up by immune cells in a CpG motif-independent manner is translocated into endosome. Endosomal maturation is essential for subsequent bacterial DNA-mediated signal transduction. TLR9 is recruited into endosome to recognize bacterial DNA and initiate the TLR/IL-1R signal transduction pathway. As a result , transcription factors NF-?B and AP-1 are activated, which, in turn, leads to proinflammatory cytokine expression and induces a strong acute Th1-like inflammatory response.
