The abnormalities of microenvironment in myelodysplastic syndrome
- VernacularTitle:骨髓增生异常综合征中的微环境异常
- Author:
Jun QIAN
;
Zixing CHEN
- Publication Type:Journal Article
- Keywords:
Myelodysplastic syndromes;
Microenvironment;
Apoptosis;
Neovascularization
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Myelodysplastic syndrome (MDS) is considered as a preleukemic course, characteristic of hypercellular marrow and pancytopenia. Many studies have demonstrated that defects occur in the heamtopoietic cells from patients with MDS. Recently, many abnormal changes in apoptosis, proliferation, ability of hematopoietic support, cytokine secretion, clonal origin of stromal cells and angiogenesis have also been revealed in the bone marrow microenvironment of MDS patients.
