Hepatoprotective effects of recombinant human growth hormone in rats with thioacetamide-induced cirrhosis
- VernacularTitle:生长激素抗肝纤维化的作用及其机制
- Author:
Shuang CHEN
;
Hongtao WANG
;
Yuru FU
;
Qingjia OU
- Publication Type:Journal Article
- Keywords:
Cirrhosis;
Fibrosis, hepatic;
Portal hypertension;
Human growth hormone, recombinant
- From:
Chinese Journal of General Surgery
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism by which recombinant human growth hormone (rhGH) protects liver function and alleviates portal hypertension in rats with liver cirrhosis. Methods Male S.D. rats with thioacetamide-induced liver cirrhosis were randomly assigned to receive separately normal saline (NS, 0.5 ml) or rhGH(333 ng/kg body weight) daily by subcutaneous injection for up to 7 days. After the respective treatments, changes of GH-binding capacity (R T), GHRmRNA, relative content of collagen (RCC), malon-dialdehyde (MDA), superoxide dismutase (SOD) in liver tissue, serum albumin and ALT and portal vein pressure (PVP) were examined. Results R T (fmol/mg protein) of GHR was respectively 31?4, 40?7(P
