Effects on Gastric Secretion and Anti-gastric Ulcer Action of Sea Buckthorn Pulp Oil in Rats
- VernacularTitle:沙棘果肉油对大鼠胃液分泌的影响及抗胃溃疡作用
- Author:
Jianfeng XING
;
Jiayu HOU
- Publication Type:Journal Article
- Keywords:
sea buckthorn pulp oil;
gastric ulcer model;
gastric acid;
pepsin;
ga stric mucus;
analgesic effect
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effects on gastric secretion and anti-gastr ic ulcer action of sea buckthorn pulp oil(SBPO)in rats METHODS:The effects of SB PO on gastric secretion in rats were studied with pylorus ligation The anti-ga stric ulcer actions of SBPO was observed on the gastric ulcer models induced by water immersion stress,reserpine,pylorus ligation or acetic acid The analgesi c effect was tested by the hot-plate method and writhing method RESULTS:SBPO significantly inhibited the secretion of gastric acid and pepsin and promoted th e secretion of gastric mucus SBPO markedly protected the formation of gastric u lcer induced by water immersion stress,reserpine or pylorus ligation and promot ed the healing of acetic acid induced gastric ulcer SBPO significantly decrease d the number of twisting body in mice CONCLUSION:SBPO has anti-gastric ulcer effect The mechanisms of anti-gastric ulcer action might be its effects of inh ibition of the secretion of gastric juice,promotion of the secretion of gastric mucus and analgesic effect
