Determination of Edaravone Contents in Injection by RP-HPLC
- VernacularTitle:反相高效液相色谱法测定易达拉封注射液的含量
- Author:
Tao GUO
;
Xuehui SUN
;
Hongtao SONG
;
Shengchuan GAO
;
Ye AN
- Publication Type:Journal Article
- Keywords:
Edaravone injection;
RP-HPLC;
content
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a method for determination of Edaravone cont en ts in injection METHODS:The Kromasil C18 column(4 6mm?200mm,5?m) was use d The mobile phase was consisted of 0 1mol/L NaH2PO4-methanol(45∶55) with detection at 242nm,flow rate was 1 0ml/min RESULTS:The linear range was 1 2 4?g/ml～24 8?g/ml(r=0 9 999),the mean recovery was 100 3% with RSD=0 9 5%(n=6) CONCLUSION:This method is simple,sensitive and accurate,and can b e used to control the quality of Edaravone injection
