Grading of mucosal histological biopsies, clinical appearances and endoscopies in patients with active ulcerative colitis
- VernacularTitle:活动期溃疡性结肠炎活检黏膜的组织学分级与临床分级和内镜分级的关系
- Author:
Yingqiang ZHONG
;
Zhaohua ZHU
;
Lianchun XING
;
Al EL
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Pathology;
Clinical;
Endoscopies;
Fractionation
- From:
Chinese Journal of Digestive Endoscopy
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations between histological grading of the mucosal biopsies, clinical appearances and endoscopies of patients with active ulcerative colitis ( AUC) , and their roles in the therapeutic outcomes. Methods To analyze the grading in pathological, endoscopic and clinical manifestations of 133 patients, and use the scores to estimate each clinical appearance. A prospective study and Spearman correlation coefficients analysis were taken in this study. Results Among 133 patients, the grading of histological, clinical and endoscopic results in grades Ⅰ ,Ⅱ , Ⅲ , andⅣwere 29,45 ,37 and 22; 85 , 39,9 and 0; 8,30,16 and 79 cases respectively. There were significant positive correlations between histological grading and the following parameters; melena ( r =0. 49, P= 0. 000) , bowel movement ( r =0. 30, P = 0.001) , ESR (r=0. 42, P =0.000) , AI(r=0.56, P=0.000) , clinical grade (r=0.52, P=0.000) endoscopic grade (r = 0. 35 , P =0. 000). And no significant negative correlation with Hb (r = -0. 13, P = 0. 125). In 68 mild and moderate cases after administered SASP for 6 weeks with clinical remission there were 16 and 19 cases with 0 grade in endoscopies and histology respectively, and in the former group 7 cases fall in histological grade I . Conclusion There was no agreement in the clinical, endoscopic and histological grades of the AUC patients. For the evaluation of therapy, the sequence of priority is histological grade, endoscopic grade, and then clinical grade.
