Expression and Significance of I?B kinase-? mRNA in the Lung Tissues of Rabbits Following Hemorrhagic Shock
- VernacularTitle:急性肺损伤肺组织I?B激酶-?mRNA的表达及意义
- Author:
Wen YIN
;
Xiaomin HU
;
Jing YUAN
- Publication Type:Journal Article
- Keywords:
Hemorrhagic shock;
Lung;
I?B kinase-?;
Nuclear factor-?B;
Tumor necrosis factor-?
- From:
Journal of Chinese Physician
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and significance of I?B kinase-?(I?K-?) in the lung tissues of rabbits with hemorrhagic shock.Methods The expressions of I?K-? and NF-?B in the lung tissues and the concentration of tumor necrosis factor-?(TNF-?) in the plasma were measured by in situ hybridization(ISH),immunohitochemistry and enzyme linked immune adsorbent analysis(ELISA), respectively. And the pathological changes were examined with light microscope in lung tissues.Results In hemorrhagic shock group,the expressions of I?K-?(0 1685?0 0164)and NF-?B( 0 1469?0 0083)in lung tissues , the level of TNF-?(636 72?100 23) in the plasma were obviously higher than those of normal group [I?K-?(0 0427?0 0241),NF-?B(0 0358?0 0048),TNF-?(199 51?35 69)ng/L](all P
