Expression of HSP70 in Basal Cell Carcinoma and Squamous Cell Carcinoma
- VernacularTitle:HSP70在皮肤基底细胞癌和鳞状细胞癌中的表达
- Author:
Ying ZHOU
;
Rong XIAO
;
Jing ZHANG
- Publication Type:Journal Article
- Keywords:
HSP;
BCC;
SCC
- From:
Journal of Chinese Physician
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression and role of HSP70 in human epidermis and cutaneous neoplasms.Methods 56 cases of epidermis tumors,including 29 biopsy samples from basal cell carcinoma, 27 from squamous cell carcinoma,and 30 from normal human skin were investigated. HSP70 expression was examined by immunohistochemical SABC staining with specific monoclonal antibodies.Results The expression of HSP70 was detectable in the cytoplasm throughout the epidermal cell layers in normal human epidermis,HSP70 expression in the tumor cells in basal and squamous cell carcinomas was reduced (P
