Change of Vascular Endothelial Growth Factor (VEGF) and its Significance in Placenta for Patients With Intrahepatic Cholestasis in Pregnancy
- VernacularTitle:妊娠肝内胆汁淤积症患者胎盘血管内皮生长因子的变化及其意义
- Author:
Songyun XIA
;
Zhuqin CHEN
;
Li LI
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factor;
Intrahepatic cholestasis of pregnancy;
Placenta;
Fetal distress
- From:
Journal of Chinese Physician
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of vascular endothelial growth factor (VEGF) in placenta for patients with intrahepatic cholestasis of pregnancy in order to search the pathogenesis of intrahepatic cholestasis of pregnancy(ICP).Methods 33 ICP patients and 30 normal advanced pregnancy (NLP) were studied.The distribution of VEGF expression and blood capillaries density in placenta were detected respectively by s-ABC immunohistochemistry,and by western blot method.Results The distribution of VEGF in placenta was similar those of ICP and NLP ,but level of expression of VEGF in placenta was significantly lower in ICP than that of NLP (P
