Cell proliferation and nestin expression in cortex and SEZ of MCAO rats
- VernacularTitle:脑缺血大鼠大脑皮层和室管膜下区细胞增殖及巢蛋白表达
- Author:
Hu CHEN
;
Dingfang CAI
;
Hui LIANG
;
Jiesh CHENG
- Publication Type:Journal Article
- Keywords:
Brain ischemia;
Rats;
Stem cells;
Cerebral cortex;
Subependymal zone;
Nestin
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of brain ischemia injury on cell proliferation and nestin expression in cortex and subependymal zone (SEZ). METHODS: Using a local brain ischemia model(MCAO), BrdU positive cells of cortex and subependymal zone (SEZ), also nestin positive cells, were observed by immunohistochemistry. RESULTS: BrdU and nestin positive cells in SEZ of MCAO rats were obviously increased. In cortex, only nestin positive cells were observed. CONCLUSION: Neural stem cells in SEZ and cortex were activated after brain ischemia, it may be related with neural recovery after brain ischemia injury.
