Role of synovium macrophage during adjuvant arthritis in rat articular damage
- VernacularTitle:佐剂性关节炎大鼠滑膜巨噬细胞在关节破坏中的作用
- Author:
Lie DAI
;
Chiduo XU
;
Meian TANG
;
Ya DOU
- Publication Type:Journal Article
- Keywords:
Arthritis, experimental;
Synovitis;
Macrophages;
Arthritis,rheumatoid
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the role of synovium macrophage of adjuvant arthritis (AA) rats in articular damage. METHODS: AA was induced in female Wistar rats by means of intradermal injection with complete Freud's adjuvant. X-ray on hind paws of AA rats was took at different time points and radiograph index (RI) was then evaluated. Synovium macrophages were detected through immunohistochemistry with ED 1 monoclonal antibody. The correlations between RI and synovial lining layer count/synovium macrophage count were also analysed. RESULTS: Synovial lining layer count, both macrophage count in synovial lining layer and sublining layer were positively correlated with RI. CONCLUSION: Synovium macrophages of AA rats may play an important role in articular damage.
