Effects of sulphated heparin on proliferation and apoptosis of human hepatocellular carcinoma cell line (HepG2)
- VernacularTitle:硫酸肝素对人肝癌HepG2细胞系增殖和凋亡的影响
- Author:
Keqin XIA
;
Haiwei ZHANG
;
Pei ZHENG
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Proliferation;
ras proteins;
Heparin;
Signal transduction;
Apoptosis
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect and the mechanism of sulphated heparin on the proliferation and the apoptosis of human hepatocellular carcinoma cells. METHODS: The human hepatocellular carcinoma cell line (HepG-2) was used to identify the expression of ras gene protein and to study the effect of sulphated heparin on proliferation and the apoptosis in vitro . RESULTS: The sulphated heparin downregulated the ras protein expression and inhibited the cell growth in HepG2 cells. In the presence of sulphated heparin, the apoptosis rate of HepG2 increased. CONCLUSION:The data suggest that the effects of sulphated heparin on the proliferation and the apoptosis of the human hepatocellular carcinoma cell are correlated with the signaling transduction mediated by ras gene protein.
