Ultrastructural,physiological and biochemical study on multiple organ dysfunction syndrome in the elderly rats
- VernacularTitle:大鼠老年多器官功能障碍综合征生理、生化及超微结构的变化
- Author:
Hualan JING
;
Yanrong LI
;
Jinlang WU
;
Jiaping LIU
- Publication Type:Journal Article
- Keywords:
Multiple organ failure;
Ultrastructure;
Vascular endothelial cells, Microscopy, electron
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: By studying the ultrastructure of organs (hearts, brains, lungs, livers, kidneys) and vascular endothelial cells, and changes of physiological and biochemical indexes with multiple organ dysfunction syndrome in the elderly rats, their signification and their developing rules were analyzed. METHODS: Wistar rats(Half of Wister rats were three-month-old and another half of twenty-month-old) were anaesthetized and dealt with cecal ligation puncture (CLP) operation. They were defined as MODSE group and MODSY group, respectively. They were perfused through all vascular circulation by 1% glutaric dialdehyde. These slices were observed under transmission electron microscopy. RESULTS: Physiological and biochemical indexes at 24 huor in elder rats were shown significant difference compared with the younger rats ( P
