Intracellular signal transduction pathway of integrin and hepatic stellate cell behavior
- VernacularTitle:整合素细胞信号转导通路与肝星状细胞行为
- Author:
Xiaolan ZHANG
;
Huiqing JIANG
- Publication Type:Journal Article
- Keywords:
Integrins;
Focal adhesions;
Mitogen-activated protein kinase;
Hepatocytes;
Proliferation;
Apoptosis
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Integrins are the main mediators of the complicated interaction between hepatic stellate cells (HSCs) and extracellular matrix (ECM) components. Signal transduction by integrins is initiated by both occupancy and crosslinking of integrins by ECM components. Focal adhesion kinase (FAK) and mitogen- activated protein kinase (MAPK), which are the downstream molecules, involve in integrin-mediated cellular behaviors. In this review, we briefly summarize the integrin's structure, intracellular signaling cascades and its role in HSC behaviors,such as activation,proliferation and apoptosis.
