Effect of propofol on dopamine uptake by dopamine transporter in Chinese hamster ovary cells
- VernacularTitle:异丙酚对多巴胺转运蛋白转运功能的影响
- Author:
Chunfan WANG
;
Guoqin SUN
;
Huifang XV
- Publication Type:Journal Article
- Keywords:
Propofol;
Dopamine;
Carrier proteins;
CHO cells
- From:
Chinese Journal of Anesthesiology
1996;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine if propofol can affect uptake of dopamine ( DA) by dopamine transporter (DAT) . Methods Chinese hamster ovary (CHO) cells in which DAT was highly expressed were incubated with H-dopamine in the presence or absence of propofol. Uptake of H-DA was measured. The kinetic parameters Vmax and Km were calculated. Results Propofol significantly inhibited uptake of DA by DAT in CHO cells as compared with the control ( P
