Effects of Clarithromycin and Fleroxacin on Pseudomonas Aeruginosa Biofilm in Vitro
- VernacularTitle:克拉霉素/氟罗沙星对铜绿假单胞菌生物被膜体外作用研究
- Author:
Hao LI
;
Ya WANG
;
Xiaoju ZHANG
;
Zhidong WANG
;
Hemin HU
;
Jinling CHENG
- Publication Type:Journal Article
- Keywords:
Pseudomonas aeruginosa;
biofilm;
clarithromycin;
fleroxacin
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effects of clarithromycin and fleroxacin on Pseudomonas aeruginosa(PA) biofilm METHODS:Clinical isolates of 7 strains of PA from respiratory tract were cultured with modified plate culture method;bacterial biofilm model was identified by silver nitrate staining;MICs were determined by broth microdilution The number of viable bacteria in biofilm was measured by using MTT method and bacterial adherence was measured by crystal violet staining RESULTS:1/16MIC and 1/4MIC of clarithromycin could inhibit the adherence of PA to silica-gel film(P
