Preparation of Fluconazole-?-Cyclodextrin Inclusion Complex
- VernacularTitle:氟康唑?-环糊精包合物的制备
- Author:
Zhiqing ZHANG
;
Juan LI
;
Jian LIU
- Publication Type:Journal Article
- Keywords:
fluconazole-?-cyclodextrin inclusion complex;
preparation;
determination of content;
dissolubility;
identification
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the preparation technic and determination of the content and dissolubility of the fluconazole-?-cyclodextrin inclusion complex(FCIC) METHODS:The FCIC was prepared by coprecipitation method and ultr_asonic method The content and percentage of the accumulated dissolubility of FCIC were determined by UV-spectrophotometry RESULTS:Fluconazole and ?-cyclodextrin could form inclusion complex through either preparation technology The contents of fluconazole in the complex were(11 34?0 77)% and(11 23?0 24)% respectively The dissolubility met the standard in CP CONCLUSION:Stable complex could be formed between fluconazole and ?-cyclodextrin
