Analysis of Co. Metrozole Injection by the Signal Conversion Combined with Multicomponent Calibration Methods
- VernacularTitle:信号变换-多元校正方法对复方甲硝唑注射液的分析
- Author:
Yajie XU
;
Mingyan JIANG
- Publication Type:Journal Article
- Keywords:
derivate MLR;
derivate PLS;
co metrozole injection;
metrozole;
chloromycetin
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyse compound pharmaceutical preparations by the signal conversion combined with multicomponent calibration methods METHODS:One-order derivative spectrum data was obtained by one-order derivative conversion On the basis of this,we combined them with the MLR method and PLS method to determine the contents of metrozole and chloromycetin in co metrozole injection RESULTS:The labelling quantity and RSD(n=5) were:metrozole 99 6%,0 11%;chloromycetin 99 3%,0 20% by derivate-MLR;The labelling quantity and RSD(n=5) were:metrozole 97 5%,0 43%;chloromycetin 94 6%,0 89% by derivate-PLS respectively CONCLUSION:One-order derivative spectrum signals aplied to the MLR method is better than the D1 PLS method
