Study on Apoptosis and Expression of Fas, FasL in Placenta of Intrahepatic Cholestasis of Pregnancy
- VernacularTitle:妊娠肝内胆汁淤积症胎盘细胞凋亡与Fas、FasL的研究
- Author:
Dongmei WANG
;
Xiaolin LA
;
Li DING
- Publication Type:Journal Article
- Keywords:
Pregnancy complications;
Cholestasis, intrahepatic;
Placenta;
Apoptosis;
Antigens,CD95;
Membrane proteins
- From:
Chinese Journal of Perinatal Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of gene Fas and FasL expression in apoptosis of plcenta with ICP. Methods TUNEL (TdT-mediated dUTP nick end labeling) and immuno-hisochemistry methods were used for 31 placental samples with ICP and 31 normal placental samples to detect apoptosis index (AI) and the expression of Fas and FasL in placental tissues. Results AI of cytotrophoblast, syncytotrophoblast, decidual cells and mediate cell(49.09?9.13,t=13.41;46.64?9.77,t=12.16;35.09?9.49,t=8.43;38.74?9.70,t=11.28) in ICP group was significantly higher than that of control group (P
