Evaluation on Clinical Application of Three Testing Methods for Human Cytomegalovirus Infection in Pregnancy
- VernacularTitle:孕妇人巨细胞病毒感染三种检测方法的临床应用价值分析
- Author:
Wanjiang ZENG
;
Liangzhen WEN
;
Suhua CHEN
- Publication Type:Journal Article
- Keywords:
Cytomegalovirus infections;
Enzyme-linked immunosorbent assay;
Polymerase chain reaction;
Pregnancy complications, infections
- From:
Chinese Journal of Perinatal Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the testing value of ELISA, N-PCR and RT-PCR in clinical practice for pregnant women with HCMV infection. Methods 5581 pregnant women were screened by ELISA. 100 cases with positive IgM (group 1), 69 positive IgM combined with positive serous DNA (group 2) and 69 with positive mRNA (group 3) were studied on maternal-fetal transmission and pregnancy outcome. Results The accordance rate of group 3 and group 2 with group 1 are 56.25% and 43.75%, respectively. The maternal-fetal transmission rate in three groups is 19.00%,40.58% and 46.15%, respectively. A significant difference existed between group 2, 3 and group 1(P0.05). The total rate of spontaneous abortion, fetal death, fetal abnormality and neonatal death are 10.00%,15.94% and 30.77% in different groups, respectively and that of group 3, 2 are 4 and 2 times as much as that of group 1, respectively (OR=4.00, P
