Relationship Between Matrix Metalloproteinase-9 Expression in Syncytiotrophoblast and Placenta Pathological Change of Intrauterine Growth Restriction
- VernacularTitle:胎儿生长受限胎盘病理改变与绒毛滋养细胞基质金属蛋白酶9的表达关系
- Author:
Yanhong YU
;
Zhijian WANG
- Publication Type:Journal Article
- Keywords:
Fetal growth retardation;
Placenta;
Gelatinase B;
Immunohistochemistry;
Trophoblast
- From:
Chinese Journal of Perinatal Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between matrix metalloproteinase-9 in syncytiotrophoblast and placenta pathological change of fetal growth restriction. Methods The placental samples were collected from 30 patients with FGR and 30 normal pregnant women who delivered in our hospital from January 2001 to September 2001. The tissue sections were dealt with HE stain and PAS stain and then observed by microscope to find the morphological change. 5 another samples from each group were observed by 500H model electron microscope. Immunohistochemical analysis was employed to demonstrate the positive expression of the MMP-9 in syncytiotrophoblast of FGR placenta. Results There are significantly pathological change in 22 placentas of FGR and abnormal rate is 73.33%. The count of stroma fibrosis and fibrinoid necrosis of villi(63.3%), villous vascular decrease and gore(70.0%), villous syncytial knots(43.3%), cytotrophoblasts increase(50.0%) were more significant in the placenta of FGR group than that of normal group(6.7%,10.0%,3.3%,13.3%)(P
