Effects of Valsartan and Spironolactone on Growth Factors and Type Ⅰ Collagen in Aorta in Spontaneously Hypertensive Rat
- VernacularTitle:缬沙坦和螺内酯对高血压大鼠血管生长因子和Ⅰ型胶原的影响
- Author:
Gangying HU
;
Jinming WANG
;
Qizhu TANG
- Publication Type:Journal Article
- Keywords:
Valsartan;
Spironolactone;
Vascular fibrosis;
Hepatocyte growth factor
- From:
Journal of Chinese Physician
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of angiotensin Ⅱ(AngⅡ) AT 1 receptor antagonist,valsartan and mineralocorticoid receptor antagonist,spironolactone on growth factors and type Ⅰ collagen in aorta in spontaneously hypertensive rat(SHR).Methods Six-week male SHRs were divided into three groups at random:SHR control group,valsartan group and spironolactone group;six homogenous Wistar Kyoto(WKY) rats was served as normal control group.Valsartan 30mg?kg -1 ?d -1 ,spironolactone 20mg?kg -1 ?d -1 were respectively administered to rats in valsartan group and spironolactone group.Expressions of transforming growth factor ? 1(TGF ? 1),hepatocyte growth factor(HGF) and type Ⅰ collagen gene mRNA in aorta were determined by RT-PCR.Results Compared with those of untreated SHR group,levels of TGF?1 and type Ⅰ collagen gene mRNA expression in aortas treated with valsartan and spironolactone for 13 weeks were significantly reduced(P
