Effect of Valsartan on Expression of MCP-1 in the Myocardium of Diabetic Rats
- VernacularTitle:缬沙坦对糖尿病大鼠心肌MCP-1表达的影响
- Author:
Yingchun YE
;
Jing LI
;
Peizheng GAN
- Publication Type:Journal Article
- Keywords:
Diabetic mellitus;
Diabetic cardiomyopathy;
Valsartan;
Monocyte chemoattractant protein-1
- From:
Journal of Chinese Physician
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of valsartan on expression of MCP-1 in the myocardium of diabetic rats,to investigate the protective effect of valsartan on the myocardium of diabetic rats.Methods 30 rats were divided into at random:normal control group(NC group),diabetic model group(DM group),diabetic model plus valsartan therapy group(DV group).Diabetic rats were induced by STZ,at 8th week,expression of MCP-1 in the myocardium of diabetic rats,and diabetic rats treated with valsartan was detected respectively by using immunohistochemistry.Results At 8th week,the expression of MCP-1 of DM group was much higher than in both DV group and NC group(P
