Inhibitory effect of kringle 4-5 on experimental choroidal neovascularization
- VernacularTitle:血管生成抑制因子k4k5对实验性脉络膜新生血管的抑制作用
- Author:
Hao WANG
;
Wenji WANG
;
Houyan SONG
- Publication Type:Journal Article
- Keywords:
Choroidal neovascularization/therapy;
Angiogenesis inhibitor;
Plasmin;
Disease models, animal
- From:
Chinese Journal of Ocular Fundus Diseases
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether kringle 4-5 could inhibit choroidal neovascularization (CNV) in mice induced by argon laser photocoagulation. Methods Fundus laser photocoagulation was performed on C57BL/6J mice to induce CNV. In treatment group, 20 ?g (low dosage group) and 50 ?g (high dosage group) kringle 4-5 were injected retrobulbarly after photocoagulation. In control group, equilibrium liquid was injected retrobulbarly. Choroidal neovascularization was evaluated on the 7th and 14th day after photocoagulation by fundus fluorescein angiography. The mice were killed on the 14th day after photocoagulation, the lesions were evaluated histologically and immunohistochemically, and the expression of CD105 was detected. The Expression of VEGF and bFGF was detected by immunohistochemistry on the 4th day after photocoagulation. Results The incidence of CNV was 64.3% in control group, 51.2%(P
