Expressive varieties of Nogo-A mRNA in injured optic nerves
- VernacularTitle:视神经损伤后Nogo-A mRNA表达的变化
- Author:
Jian YE
;
Zhengguo WANG
;
Peifang ZHU
- Publication Type:Journal Article
- Keywords:
Optic nerve Injury;
Nerve growth factor/antagonists & inhibitors;
Reverse transcritase polymerase chain reaction;
Disease models, animol
- From:
Chinese Journal of Ocular Fundus Diseases
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expressive varieties of Nogo-A mRNA in injured optic nerves of rats. Methods Reverse transcription polymerase chain reaction (RT-PCR) method was used to hemi-quantitatively analyze the levels of Nogo-A mRNA in the optic nerves 3, 7, 9, 15, 21, and 25 days respectively after injury. Results The level of the expression of Nogo-A mRNA was low in the normal optic nerves, while it was significantly high in the optic nerves 3 days after injury, and kept the high level still after 25 days. Conclusion The expression of Nogo-A mRNA in injured optic nerves is increased.
