Clinical Significance of Nucleosomes Released from Peripheral Blood Mononuclear Cells of Patients with Systemic Lupus Erythematosus
- VernacularTitle:系统性红斑狼疮患者外周血单一核细胞核小体释放水平及其临床意义
- Author:
Jin HAO
;
Fei HAO
;
Baiyu ZHONG
;
Yunsheng XU
;
Shuqian TANG
;
Xiaoyun GONG
;
Qingyi YE
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Lymphocytes;
Nucleosomes;
Antibodies,antinuclear
- From:
Chinese Journal of Dermatology
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the levels of nucleosomes released from peripheral blood mononu-clear cells(PBMC)of patients with systemic lupus erythematosus(SLE),and their relationship with auto-antibodies as well as disease activity.Methods Levels of both nucleosomes released from PBMC and vari-ous auto-antibodies were detected by ELISA in sera from SLE patients.The disease severity was evaluated using SLEDAI(systemic lupus erythematosus disease activity index)system.Results Levels of nucleosomes released from PBMC were significantly higher in patients with active SLE than those of patients with inactive disease and normal controls(39.39?25.70,13.44?8.82,and11.73?7.87IU/mL,respectively).There was a significant positive correlation between nucleosome levels and SLEDAI scores,serum ds-DNA auto-an-tibody levels,and low C3levels.Conclusion Nucleosomes released from apoptotic PBMC of patients with SLE is closely correlated to disease activity,which implies that nucleosomes may play an important role in the pathogenesis of SLE.
