Relationship Between Erythrocyte CR1Activity and CR1Genomic Density Polymorphism in Patients with System Lupus Erythematosus(SLE)
- VernacularTitle:系统性红斑狼疮患者红细胞补体受体Ⅰ型密度相关基因组多态性研究
- Author:
Feng GUO
;
Junjie ZHANG
;
Yu XU
;
Baohua QIAN
;
Meixian HUA
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Receptors,complement3b;
Antigen-antibody com-plex;
Polymorphism(Genetics)
- From:
Chinese Journal of Dermatology
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study complement receptor typeⅠ(CR1)activity of erythrocytes in pa-tients with SLE.Methods Using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),CR1rosette(RBC-CR1R)and immuno-complex rosette(RBC-ICR)on red cell,the ery-throcyte complement receptor I type(ECR1)genomic density polymorphism(HH type,HL type,LL type)and erythrocyte CR1immune activity were determined in32patients with SLE and in48normal individuals.Results It was found that HH type rate of ECR1density polymorphism in patients with active SLE was significantly lower(10/16,62.5%)than that(13/16,81.3%)in patients with stable SLE.The level of CR1immune activity in HH type was significantly higher than that in HL,LL type of SLE,and significantly dif-ferent from that in48normal individuals(P
