Levels of Nitric Oxide and Some Cytokines in Sera and Suction Blister Fluid in Patients with Vitiligo
- VernacularTitle:白癜风患者血清及负压吸引疱疱液一氧化氮及相关细胞因子检测
- Author:
Xuejing TAN
;
Caixia TU
;
Yanjie CHENG
;
Xiran LIN
- Publication Type:Journal Article
- Keywords:
Vitiligo;
Nitric oxide;
Interferon typeⅡ;
Interleukin-10;
Interleukin-12
- From:
Chinese Journal of Dermatology
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between nitric oxide(NO)and some cytokines and the pathogenesis of vitiligo.Methods Nitric acid reductase assay and ELISA were used to determine the serum levels of NO,and IFN-?,IL-10and IL-12in32patients with vitiligo,compared with18normal controls.The levels of these molecules in suction blister fluids,including involved skin and uninvolved skin from20patients,were also determined.Results The serum levels of NO and IFN-?in vitiligo patients were significantly higher than those in controls,and the serum level of IL-10in the patients was significantly lower than that in controls.The serum level of IFN-?in generalized type of vitiligo and the serum level of NO in localized type of vitiligo in active stage were higher than those in stable stage.The NO level in suction blister fluid of localized vitiligo of involved skin was significantly higher than that of uninvolved skin.Conclusion These findings suggest that NO,IFN-?and IL-10might be involved in the pathogenesis of vitiligo.
