Effects of c-myb antisense RNA on the proliferation and collagen Ⅰ gene expression in cultured hepatic stellate cells
- VernacularTitle:逆转录病毒介导的反义c-myb对肝星状细胞增殖及Ⅰ型胶原基因表达的影响
- Author:
Huihui MA
;
Jilu YAO
;
Chunlan YAO
;
Gang LI
;
Xuejuan CHEN
;
Lin GU
;
Shaoji YANG
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Genes, Antisense;
Genes,c-myb;
Hepatic stellate cells
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
98%. In the pDOR-myb infected HSCs, c-myb expression levels, the cell proliferation, and ? 1-Ⅰ collagen mRNA expression were repressed significantly. CONCLUSIONS: c-myb plays a key role in the activation and proliferation of HSC. c-myb antisense RNA can inhibit cell proliferation and ? 1-Ⅰ collagen mRNA expression in the infected HSC. These data suggest that inhibition of c-myb gene expression would be a potential way for the treatment of liver fibrosis.
