Renal function damage induced by acute lung injury in aging rats
- VernacularTitle:衰老大鼠急性肺损伤诱导肾功能受损
- Author:
Jian ZHANG
;
Yewei DU
;
Renyu SUN
;
Shiwe WANG
- Publication Type:Journal Article
- Keywords:
Respiratory distress syndrome, acute;
Lipopolysaccharides;
Kidney function;
Aging
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate whether renal function damage could be induced by acute lung injury(ALI)in aging rats. METHODS: 40 Wistar male rats were used for reproducing aging animal model. Aging rats were randomly divided into aging control; ALI group (Lipopolysaccharide, LPS, 5 mg/kg body weight, iv) and LPS group (same dosage LPS, intraventricle of left heart injection). The samples (blood, lung and kidney ) were collected at 2 or 6 hours after LPS or normal saline administration. RESULTS:Compared with aging control, in ALI group, creatinine (Cr) and urea nitrogen (BUN) contents in blood were increased significantly (all P
