Protection of L-glutamine against myocardial cell injury induced by endotoxin
- VernacularTitle:谷氨酰胺对内毒素损伤的心肌的保护作用研究
- Author:
Renbin QI
;
Daxiang LU
;
Huadong WANG
;
Haihua WANG
;
Chaofeng HU
;
Yang QU
;
Huijie YANG
;
Yanping WANG
;
Yongmei FU
;
Chuji LI
- Publication Type:Journal Article
- Keywords:
Glutamine;
Endotoxins;
Myocardium
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe protective effect of L-glutamine on myocardial cell injury induced by endotoxin. METHODS:22 male SD rats,weighting(250?30)g,were randomly divided into three groups:control group( n= 7),endotoxin group( n= 7),glutamine/endotoxin group( n= 8). Heart were isolated from rats and perfused on Langendorff apparatus with Krebs- Henseleit(K-H)buffer(Saturation 95%O 2+5%CO 2)at a constant pressure(8.33 kPa)and temperature(37℃). The activity of superoxide dismutase (SOD)and malondialdehyde (MDA)content of efflux from coronary artery, monophasic action potential(MAP)and contractile force were measured at certain timepoints (0 min,20 min,50 min,80 min). RESULTS: Monophasic action potential and contractile force were markedly improved in Gln/ET group. The activity of SOD and MDA level in Gln/ET group restored closely to that in control group. CONCLUSION:L-gluta mine protects myocardial cells from injure induced by endotoxin.
