Changes of urinary albumin and N-acetyl-beta-glucosaminidase in high altitude polycythemia at different altitudes and its mechanism
- VernacularTitle:不同海拔高度高原红细胞增多症患者尿白蛋白和N-乙酰-?-D-氨基葡糖苷酶的排泄变化及其机理的探讨
- Author:
Aiqi XI
;
Yide CHU
- Publication Type:Journal Article
- Keywords:
Altitude;
Polycythemia;
Glucosaminidase;
Albuminuria;
Superoxide dismutase;
Malondialdehyde;
Erythrocyte deformability
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the changes of excretive amount of albumin(ALB) , N-acetyl-beta-D-glucosaminidase(NAG) in patients with high altitude polycythemia(HAPC) at different altitude and its mechanism. METHODS: Urinary ALB, NAG, activity of red blood cell superoxide dismutase(RBC-SOD), malonyldialdehyde(MDA) and erythrocyte filtration index(EFI) of 231 healthy subjects and 86 patients with HAPC at different altitude were detected. RESULTS:Excretive amount of urinary ALB, NAG, and plasma MDA, EFI were higher,and RBC-SOD was lower in patients with HAPC than those in healthy subjects, the changes were significantly obvious, with increasing altitude. Urinary ALB and NAG were negatively correlates to EFI, and no correlated to the content of MDA and RBC-SOD. CONCLUSIONS: EFI exertes an independent influence on urinary ALB and NAG. The decrease in erythrocyte deformability caused by the increase of peroxidation of lipids might participate in the pathogenesis and progress of the increase of excretive amount of ALB and NAG in HAPC.
