Alteration of Na~+ currents in ventricular myocytes from 1-week infarcted rabbit heart
- VernacularTitle:急性心肌梗死后1周兔心室肌细胞钠离子通道活性的变化
- Author:
Chao DING
;
Zhenshan HE
;
Shuying QI
;
Junyu CUI
;
Li YANG
;
Liye HU
;
Qiao SHI
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Sodium channels;
Myocardium;
Rabbits
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the current density and function of Na + channel in cells from the epicardial border zone of the 1-week infarcted rabbit heart. METHODS: Rabbits were infarcted by ligation of the left anterior descending coronary artery. 1 week later, I Na was recorded using whole cell patch-clamp techniques in ventricular myocytes from infarcted heart(IZs) and compared with the I Na from noninfarcted heart(NZs). RESULTS: Peak I Na current density(at -30 mV) was significantly reduced in IZs(22 48?4 62 PA/PF, n= 14) compared with NZs(45 50?5 33 PA/PF, n= 12), P
