Effect of Xingnaojing Injection on PMN Adhering to BMVEC in Vitro
- VernacularTitle:醒脑静注射液的体外抗多形核白细胞与血管内皮细胞粘附的效果
- Author:
Zhigang LI
;
Songqing LIU
;
Zhangyang WANG
- Publication Type:Journal Article
- Keywords:
Xingnaojing;
polymorphnuclear leukocyte;
vascular endothelial cell;
adhesion;
platelet activating factor;
NO
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the anti-adherence effect and its mechanism of Xingnaojing(XNJ)injec?tion.METHODS:In mixed culture of rabbit’s PMN and brain microvascular endothelial cell(BMVEC),the effects of XNJ on LPS-induced PMN-BMVEC adhesion and the changes of PAF and NO levels were observed.RESULTS:XNJ could obviously decrease the PMN-BMVEC adhesion rate and the levels of NO and PAF in culture medium.CONCLUSION:XNJ can inhibit adhesion of PMN to BMVEC and release of some inflammatory media.The decrease of some inflammatory media may related to the reduction of adhesion.
