Experimental Study of Percutaneous Absorption of Neostigmine Cream in Vitro
- VernacularTitle:新斯的明乳膏体外透皮吸收实验研究
- Author:
Weijuan ZHAO
;
Jingfeng XU
;
Jiaming BIAN
- Publication Type:Journal Article
- Keywords:
neostigmine;
azone;
percutaneous absorption
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the in vitro percutaneous absorption of neostigmine cream.METHODS:Using isolated mouse skin as permeation barrier,the influence of different concentrations of azone on percutaneous permeation of neostigmine was studied.RESULTS:Azone could obviously enhance the percutaneous permeation of neostigmine,and the accumulative permeation quantity of neostigmine cream containing2%and5%azone increased7.17%and11.87%respectively compared with that of cream without azone.CONCLUSION:The percutaneous permeability of neostigmine cream is satisfactory and the best concentration of azone in enhancing permeation seems to be5%.
