Preparation and Clinical Application of Compound Levofloxacin Eye Drops
- VernacularTitle:复方左氧氟沙星滴眼液的研制及临床应用
- Author:
Lei ZHANG
;
Yan LIN
;
Zhonghua LI
;
Yi LIANG
;
Yongjiang CHEN
- Publication Type:Journal Article
- Keywords:
levofloxacin;
eye drops;
quality control
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the preparation of compound levofloxacin eye drops and its quality control,then observe its clinical effect.METHODS:Levofloxacin was used as basic remedy mixed with dexamethasone sodium phosphate and phos?phate was adoped as buffer,while EDTA-2Na as stabilizer.Finally the content of levofloxacin was determined by UV-spec?trophotometric method.RESULTS:The preparations was stable and within the range of2～6?g/ml,the concentration of lev?ofloxacin had a linear relationship with absorbance(C=26.1780A—1.0838,r=0.9997).The average rate of recovery was100.34%and RSD was0.44%(n=5).CONCLUSION:This preparation has a good effect with simple preparing technique and reliable quality control.
