The Clinical Effect and Cost-effectiveness Analysis of Granisetron and Ondansetron in the Prevention of Nausea and Vomiting Induced by Cisplatin
- VernacularTitle:格拉司琼与恩丹西酮预防顺铂所致呕吐的疗效及费用-效果分析
- Author:
Wei LEI
;
Jingjuan ZHU
;
Jun LIANG
- Publication Type:Journal Article
- Keywords:
Granisetron;
Ondansetron;
Cisplatin;
vomiting;
cost-effectiveness analysis
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the cost-effective ratios between Granisetron and Ondansetron in the prevention of Cisplatin-induced nausea and vomiting.METHODS:In a randomized auto-controlled design,36patients receiving chemotherapy with Cisplatin were divided into2groups to compare the antiemetic effects and toxicity between Granisetron and Ondansetron and to carry out cost-effectiveness analysis.RESULTS:Granisetron could effectively prevent Cisplatin-induced nausea and vomiting and its antiemetic effect was comparable to that of Ondansetron.The average effective rates in preventing nausea and vomiting of Granisetron and Ondansetron were75.9%,77.8%and79.7%,75.0%respectively,and there were no significant differences between two drugs.The toxic reactions of Granisetron were slight.In cost-effectiveness analysis,Granisetron was better than Ondansetron.CONCLUSION:Granisetron is a safe,effective,economical antiemotic in chemotherapy of cancers.It is worth popularizing the application.
