Factors Influencing the Serum Concentration of Valproic Acid and Countermeasures
- VernacularTitle:影响丙戊酸钠血药浓度波动的因素及应对措施
- Author:
Jinyu ZHOU
;
Kuixing WANG
;
Zengxian SUN
- Publication Type:Journal Article
- Keywords:
valproic acid;
the serum drug concentration;
influencing factor
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the factors that influence the fluctuation of serum concentrations of valproic acid and to improve the effectiveness and usefulness of monitoring the serum concentration.METHODS:The factors that influence the serum concentration of valproic acid were summed up and the countermeasures were put forward.RESULTS:These influencing factors included the drug administration time;the blood sampling time;the right moment for monitoring;the dosage forms and quality of drug;the obedience of patient;combining use of drugs and the physiological and pathological conditions of pa?tients.CONCLUSION:When epileptic patients receive long-term medical treatment,the doctor,the patient and the pharma?cist should communicate mutually,establish the relevant data,pay attention to those factors and ensure the patients safe and effective in use of drug.
