Determination the Contents of Paracetamol and Caffeine in999Ganmaoling Granules With TLC
- VernacularTitle:薄层扫描法测定三九感冒灵冲剂中对乙酰氨基酚及咖啡因的含量
- Author:
Aitao QU
;
Limin SUN
;
Aiping WEN
;
Shuang LIU
- Publication Type:Journal Article
- Keywords:
Ganmaoling granule;
paracetamol;
caffeine;
TLC scanning method;
determination of content
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To simultaneously determine the contents of paracetamol and caffeine in999Ganmaoling granules with TLC.METHODS:Chloroform-ethylacetate-methanol-annmonia water(15∶4∶3∶0.3)was taken as developing a?gent.The spots were scanned with CS-930TLC scanner at? S =245nm,? R =315nm for paracetamol and at? S =270nm,? R =350nm for caffeine.RESULTS:Average recovery of paracetamol was99.33%,RSD=1.28%;Average recovery of caffeine was100.1%,RSD=1.71%;The labelling contents of paracetamol and caffeine in three batches of samples were99.02%,98.48%,99.23%and99.74%,98.57%,99.24%respectively.CONCLUSION:The method is simple,quick and accurate.It can be used for the quality control of999Ganmaoling.
