7?-Hydroxycholesterol Reduces the Extent of Reactive Gliosis Caused by Fe~(3+)in Rat Brain
- VernacularTitle:7?-羟基胆固醇减少铁离子所致的反应性胶质增生
- Author:
Yuanrong YAO
;
Shenggang SUN
;
Etang TONG
- Publication Type:Journal Article
- Keywords:
7?-hydroxycholesterol;
Glial fibrillary acidic protein;
Ferric chlorid;
Rat
- From:
Journal of Chinese Physician
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To demonstrate anti-proliferative effect and significance of 7?-hydroxycholesterol(7? OHCH) on astrocytes.Methods Ferric chloride were given with a cortical injection rats,then immediatedly infused liposome suspension including 7? OHCH in the injury site.Glial fibrillary acidic protein(GFAP) expression in cortex was detected quantitatively by immunohistochemistry and computerized image analysis.Results The number of GFAP positive astrocytes around the injury site was decreased to baseline.Conclusions 7?-OHCH has anti-proliferative property on astrocytes,and this could facilitate the investigation on the influences of reactive gliosis on functional recovery following brain injury and other kinds of pathogenesis involving glial cell proliferation.
