A Case Report of Lymphomatoid Papulosis Followed By Mycosis Fungoides:Derived from a Com-mon T Cell Clone
- VernacularTitle:淋巴瘤样丘疹病继发蕈样肉芽肿:共同T细胞克隆增生一例报告
- Author:
Ping WANG
;
Bingsen QIU
;
Hongyang GAO
;
Minghua CHEN
;
Yifei SHAN
- Publication Type:Journal Article
- Keywords:
Lymphomatoid papulosis;
Lymphoma,T-cell;
T-lymphocytes;
Immunophenotyping
- From:
Chinese Journal of Dermatology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To report a case of lymphomatoid papulosis(LyP)followed by mycosis fun-goides(MF)during his27years course and determine whether these diseases are clonally related.Methods Characteristics of clinicopathology and immunophenotype of skin tissues of different phases of the patients were compared.Simultaneously,clonal T-cell receptor gene rearrangement of skin lesion tissues and blood specimens were detected by means of polymerase chain reaction and Southern blot analysis.Results A dis-tinct clinical and pathological feature was shown in this case of LyP followed by MF.The proliferating lym-phocytes in LyP and MF were mature T helper lymphocytes,and with same T-cell clone.Conclusion LyP followed by MF displays a same T-cell clone.The clonal T-cell is irrelevant to the biological behavior of these diseases.
