Epidermal and Dermal Distribution After Topical Application of Liposome Podophyllotoxin Suspen-sion in Rats
- VernacularTitle:脂质体鬼臼毒素混悬液在大鼠表皮及真皮的分布规律初探
- Author:
Kang ZENG
;
Sanquan ZHANG
;
Binbin JIANG
;
Ledong SUN
;
Jianhua LI
;
Xiaodong MA
;
Xiaoliang ZHU
;
Guofeng LI
- Publication Type:Journal Article
- Keywords:
Liposomes;
Podophyllotoxin;
Administration,cutaneous
- From:
Chinese Journal of Dermatology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the distribution pattern of liposome podophyllotoxin(LP)in rat skin.Methods The rats were divided into two groups:0.5%liposome podophyllotoxin suspension was ap-plied to LP group,0.5%podophyllotoxin tincture was applied to control group.The skin specimens were ob-tained1?2?4?6?12and24h after drug application,the amount of fluorescent stain was observed under con-focal laser scanning microscope and converted to the values of area under the curve(AUC).Results The epidermal AUC of fluorescent amount in LP group was1.5-fold than that in control group,dermal AUC was2.3-fold higher.The unit area fluorescent amount in both epidermis and dermis was highest2hours after topical medication in control group(1585.52/?m 2 and2005.66?m 2 ),and quickly reduced after4hours.But the epidermal and dermal unit area fluorescent amount in LP group was rather low in4hours after topi-cal medication,and gradually increased after6hours,and peaked after12hours(750.28/?m 2 and1073.08/?m 2 ).Conclusion Liposome preparation of podophyllotoxin can be slowly released and lasts longer in the skin.
