Identification of Genetic Locus for Disseminated Superficial Actinic Porokeratosis
- VernacularTitle:播散性浅表光线性汗孔角化病致病基因的定位
- Author:
Zhenghua ZHANG
;
Zhenmin NIU
;
Jingjun ZHAO
;
Xiaoyan XIONG
;
Rong ZHAO
;
Haiming ZHU
;
Yuebin LI
;
Shijie XU
;
Weida LIU
;
Wei HUANG
- Publication Type:Journal Article
- Keywords:
Disseminated superficial actinic porokeratosis;
Pedigree;
Microsatellite marker;
Genecan;
Linkage analysis
- From:
Chinese Journal of Dermatology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the genetic locus for disseminated superficial actinic porokeratosis(DSAP).Methods Genome DNA was extracted from the whole blood of the family members of a pedigree of DSAP.Genotyping on chromosome12q that had been identified was performed by using7microsatellite mark-ers to scan the family members of DSAP and analysed with LINKAGE(5.1Version).Results A maximum2-point lod score of5.15with marker D12S79at a recombination fraction(?)=0.00was found.Conclusion Our study supports that DSAP gene localizes at the long arm of chromosome12,which was first reported in the literature.
