Effects of cotransplantation of donor-derived bone marrow mesenchymal stem cells on acute graft versus host disease
- VernacularTitle:供者源性的骨髓间质干细胞对急性移植物抗宿主病的影响
- Author:
Haowei LI
;
Guanmei WEN
;
Qingzhong XIAO
;
Hongle LI
;
Lianning DUAN
;
Peng XIANG
;
Xiuming ZHANG
;
Shunon LI
- Publication Type:Journal Article
- Keywords:
Bone marrow mesenchymal stem cells;
Bone marrow transplantation;
Graft vs host disease;
Rats
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of cotransplantation of donor-derived bone marrow mesenchymal stem cells on graft versus host disease in a rat allogeneic bone marrow transplantation model. METHODS: Fisher 344 rat bone marrow MSCs were isolated and cultured to the fifth passage (P5) in vitro . The recipient Wistar rats were conditioned with lethal total body irradiation and transplanted with F344 rat bone marrow cells and spleen cells in the presence or absence of (P5) MSCs. The onset time of graft versus host disease (GVHD), incidence of GVHD and survival time were monitored. RESULTS: Cotransplantation of MSCs deferred the onset time of GVHD[(19.1?1.7) d vs (15.6?1.5) d, P
