Changes in L-arginine/nitric oxide pathway of the aorta in septic shock rats
- VernacularTitle:败血症休克大鼠血管L-精氨酸/一氧化氮途径的变化
- Author:
Jie YUAN
;
Juxiang LI
;
Baohong ZHANG
;
Xianhong DONG
;
Zhenghao ZHANG
;
Chaosh TANG
- Publication Type:Journal Article
- Keywords:
Nitric oxide;
Nitric-oxide synthase;
Arginine;
Shock, septic;
Rats;
Aorta
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the change of nitric oxide (NO) generation system in the vascular adventitia, media and intima in septic shock rats. METHODS: The septic shock model was made in rats by caecal ligation and puncture. The intima, media and adventitia of the rat aorta were separated. NO production (NO - 2) , nitric oxide synthase(NOS) activity and L-arginine (L-Arg) transport were measured, separately. Inducible NOS (iNOS) distribution was detected by immunohistochemistry. RESULTS: Both in early and late stage of septic shock, NO - 2 from the intima was decreased by 66.1% and 78.9%( P
