The dynamic changes of plasma nitric oxide and endothelin-1in prehepatic portal hypertension rats
- VernacularTitle:大鼠肝前性门静脉高压症形成中一氧化氮和内皮素-1水平的动态变化
- Author:
Bin SHI
;
Liang ZHU
;
Zhongbing ZHANG
;
Weifen XIE
;
Xingrong ZHANG
;
Yinxiang CAO
;
Qigen LI
;
Jianwe SHEN
- Publication Type:Journal Article
- Keywords:
Hypertension, portal;
Nitric oxide;
Endothelin-1
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the dynamic changes of plasma levels of nitric oxide(NO) and endothelin (ET-1) in portal veins of the rats during prehepatic portal hypertension, and investigate the role of them in hyperdynamic circulation. METHODS: The models of prehepatic portal hypertension were established in Sprague-Dawley rats by means of partial portal vein ligation (PVL). The plasma levels of nitrite/nitrate (NO - 2/NO - 3) and ET-1 in the portal veins were detected by the method of nitric reductase and radioimmunoassay, respectively. In this study, rats were divided into normal, sham operation (SO) and PVL group. SO and PVL rats were divided into several subgroups according to different time after operations. Meanwhile, the changes of several hemodynamic indexes in these rats were also measured. RESULTS: The levels of NO - 2/NO - 3 were significantly increased and ET-1 were significantly decreased in rats at different time after PVL compared with normal control, whereas the hemodynamic indexes changed accordingly. CONCLUSION: The portal hypertensive rats are in hyperdynamic circulatory state (HCS). NO and ET-1 may play an important role in the induction and maintenance of HCS.
