Expression of MMP-2 mRNA and MMP-9 mRNA in pulmonary arterioles of rats with pulmonary hypertension induced by chronic hypoxia hypercapnia
- VernacularTitle:慢性低O_2高CO_2性肺动脉高压大鼠肺血管基质金属蛋白酶基因表达
- Author:
Jiwu LI
;
Yongsheng GONG
;
Xiaofang FAN
;
Lianggang HU
;
Luzhen ZHENG
;
Zhongsun JIANG
- Publication Type:Journal Article
- Keywords:
Metalloproteinases;
Anoxia;
Hypercapnia;
Hypertension,pulmonary;
Genes
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of matrix metalloproteinases(MMPs) in pulmonary arterioles of rats with chronic hypoxia and hypercapnia-induced pulmonary hypertension. METHODS: MMP-2, MMP-9 and MMP-2 mRNA, MMP-9 mRNA were observed in pulmonary arterioles by the techniques of immunohistochemistry and in situ hybridization. RESULTS: ①The mean pulmonary artery pressure (mPAP) and weight ratio of right ventricle to left ventricle and septum (RV/LV+S) of hypoxia-hypercapnia groups were higher than those of normal control group ( P
