Influence of Xiaoke keli Ji on glycemia and serum lipoprotein levels in diabetic nephropathy rats
- VernacularTitle:消渴颗粒剂对糖尿病肾病大鼠血糖、血脂含量的影响
- Author:
Qian WANG
;
Muxin GONG
;
Hui ZHAO
;
Yuexiu WANG
;
Mei YU
;
Keling LI
;
Qifu HUANG
;
Boguang LI
;
Jin YAN
- Publication Type:Journal Article
- Keywords:
Drugs,Chinese herbal;
Diabetic nephropathies
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the changes of glycemia and serum cholesterol and triglyceride in diabetic nephropathy rats and therapeutic effects of Xiaoke Keli Ji. METHODS: 3/4 nephrectomy was adopted firstly, three weeks later streptozotocin(STZ) was administered intraperitoneally to establish diabetic nephropathy model in rats. Animals were divided into four groups:model group, Xiaoke Keli Ji treatment group, positive control group and sham group. Changes of serum sugar and serum creatinine, cholesterol and triglyceride were examined at 1, 2, 3, 4, 5 weeks after STZ injection. Renal tissue samples were adopted at 6th week and studied by light microscopy. RESULTS: Model group demonstrated different degree of glomerular sclerosis. Lesions in treatment group were alleviated. Serum creatinine, serum sugar and serum cholesterol were higher at 1, 2, 3, 4, 5 weeks after STZ injection in model group than that of the sham group ( P
