Expression of CD40-CD40L during rat myocardial ischemia-reperfusion injury
- VernacularTitle:大鼠心肌缺血再灌注损伤时粘附分子CD40及CD40配体的表达
- Author:
Yuguang LI
;
Min WU
;
Yuanchun ZHANG
;
Chunying YAN
;
Chengzhi LU
- Publication Type:Journal Article
- Keywords:
Myocardial reperfusion injury;
Cell adhesion molecules;
Antigens,CD40;
CD40 ligand
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of CD40 and CD40 ligand(CD40L) during myocardial ischemia/reperfusion injury in rats. METHODS: In the rat modal with myocardial ischemia/reperfusion(MI/R),the changes of CD40 and CD40L expression in blood and myocardial tissues were detected by flow cytometry and immunohistochemistry, respectively. There were seven animal groups in the study, including the normal group ( n= 3), the ischemia 30 min group(I 30 min , n= 6),the ischemia/reperfusion 1 min,5 min,10 min,20 min and 30 min groups(each group, n= 6). RESULTS: The indexes of the expression of CD40 and CD40L in I 30 min group were higher than those in control group,( P
